2022
Khan AA, Bilezikian JP, Brandi ML, Clarke BL, Potts JJ, Mannstadt M, on Hyperparathyroidism IWP. The Second International Workshop on the Evaluation and Management of Hypoparathyroidism. J Bone Miner Res . 2022. Publisher’s Version
Yao L, Hui X, Li M, Li J, Ahmed MM, Lin C, Kandi M, Sreekanta A, Makhdami N, Tamilselvan D, et al. Complications, Symptoms, Presurgical Predictors in Patients With Chronic Hypoparathyroidism: A Systematic Review. J Bone Miner Res. 2022. Publisher’s VersionAbstract
Mannstadt M, Cianferotti L, Gafni RI, Giusti F, Kemp EH, Koch CA, Roszko KL, Yao L, Guyatt GH, Thakker RV, et al. Hypoparathyroidism: Genetics and Diagnosis. J Bone Miner Res. 2022. Publisher’s Version
Parksook WW, Heydarpour M, Brown JM, Turchin A, Mannstadt M, Vaidya A. Evaluating the clinical and mechanistic effects of eplerenone and amiloride monotherapy, and combination therapy with cinacalcet, in primary hyperparathyroidism: A placebo-controlled randomized trial. Clin Endocrinol (Oxf). 2022. Publisher’s Version
Bilezikian JP, Khan AA, Clarke BL, Mannstadt M, Potts JT, Brandi ML. The Fifth International Workshop on the Evaluation and Management of Primary Hyperparathyroidism. J Bone Miner Res. 2022. Publisher’s Version
Bilezikian JP, Khan AA, Silverberg SJ, Fuleihan GE, Marcocci C, Minisola S, Perrier N, Sitges-Serra A, Thakker RV, Guyatt G, et al. Evaluation and Management of Primary Hyperparathyroidism: Summary Statement and Guidelines from the Fifth International Workshop. J Bone Miner Res. 2022. Publisher’s Version
Meyer MB, Benkusky NA, Lee SM, Yoon SH, Mannstadt M, Wein MN, Pike JW. Rapid genomic changes by mineralotropic hormones and kinase SIK inhibition drive coordinated renal Cyp27b1 and Cyp24a1 expression via CREB modules. . J Biol Chem. 2022. Publisher’s Version
Khan AA, Guyatt G, Ali DS, Bilezikian JP, Collins MT, Dandurand K, Mannstadt M, Murphy D, M’Hiri I, Rubin MR, et al. Management of Hypoparathyroidism. . J Bone Miner Res. 2022. Publisher’s Version
Van Uum S, Shrayyef M, M’Hiri I, Dandurand K, Ali DS, Bilezikian JP, Collins MT, Mannstadt M, Rubin MR, Siggelkow H, et al. Initial Assessment and Monitoring of Patients with Chronic Hypoparathyroidism: a Systematic Current Practice Survey. . J Bone Miner Res. 2022. Publisher’s Version
Khan AA, Bilezikian JP, Brandi ML, Clarke BL, Gittoes NJ, Pasieka JL, Rejnmark L, Shoback DM, Potts JT, Guyatt GH, et al. Evaluation and Management of Hypoparathyroidism Summary Statement and Guidelines from the Second International Workshop. . J Bone Miner Res. 2022. Publisher’s Version
Ye Z, Silverberg SJ, Sreekanta A, Tong K, Wang Y, Chang Y, Zhang M, Guyatt G, Tangamornsuksun W, Zhang Y, et al. The efficacy and safety of medical and surgical therapy in patients with primary hyperparathyroidism: a systematic review and meta-analysis of randomized controlled trials. . J Bone Miner Res. 2022. Publisher’s Version
Yao L, Guyatt G, Ye Z, Bilezikian JP, Brandi ML, Clarke BL, Mannstadt M, Khan AA. Methodology for the guidelines on evaluation and management of hypoparathyroidism and primary hyperparathyroidism. J Bone Miner Res. 2022. Publisher’s Version
Björnsdottir S, Clarke BL, Mannstadt M, Langdahl BL. Male osteoporosis-what are the causes, diagnostic challenges, and management. Best Pract Res Clin Rheumatol. 2022. Publisher’s Version
Swartling O, Evans M, Spelman T, Kamal W, Kämpe O, Mannstadt M, Trolle Lagerros Y, Björnsdottir S. Kidney Complications and Hospitalization in Patients With Chronic Hypoparathyroidism: A Cohort Study in Sweden. J Clin Endocrinol Metab. 2022;107 (10) :e4098-e4105. Publisher’s Version
Bondeson DP, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Langan C, Mesa G, Gonzalez A, Surface LE, Ito K, et al. Phosphate dysregulation via the XPR1–KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nature Cancer. 2022. Publisher’s Version
2021
Gittoes N, Rejnmark L, Ing SW, Brandi ML, Björnsdottir S, Hahner S, Hofbauer LC, Houillier P, Kahn AA, Levine MA, et al. The PARADIGHM (physicians advancing disease knowledge in hypoparathyroidism) registry for patients with chronic hypoparathyroidism: study protocol and interim baseline patient characteristics. BMC Endocrine Disorders. 2021;21 (232)
Arnold A, Dennison E, Kovacs CS, Mannstadt M, Rizzoli R, Brandi ML, Clarke B, Thakker RV. Hormonal regulation of biomineralization. Nature Reviews Endocrinology. 2021. Publisher’s Version
2020
ENCODE PC, Snyder MP, Gingeras TR, Moore JE, Weng Z, Gerstein MB, Ren B, Hardison RC, Stamatoyannopoulos JA, Graveley BR, et al. Perspectives on ENCODE. Nature. 2020;583 (7818) :693-698
ENCODE PC, Moore JE, Purcaro MJ, Pratt HE, Epstein CB, Shoresh N, Adrian J, Kawli T, Davis CA, Dobin A, et al. Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature. 2020;583 (7818) :699-710.
2019
ahn SV, Lee JV, Bove-Fenderson E, Park SY, Mannstadt M, Lee S. Incidence of Hypoparathyroidism After Thyroid Cancer Surgery in South Korea, 2007-2016. Journal of the American Medical Association. 2019;322 (24) :2441-2443. Publisher’s Version
Pages
Mannstadt M, Clarke BL, Bilezikian JP, Bone H, Denham D, Levine MA, Peacock M, Rothman J, Shoback DM, Warren ML, et al. Safety and Efficacy of 5 Years of Treatment With Recombinant Human Parathyroid Hormone in Adults With Hypoparathyroidism. Journal of Clinical Endocrinology & Metabolism. 2019;104 (11) :5136–5147. Publisher’s Version
Biebermann H, Kleinau G, Schnabel D, Bockenhauer D, Wilson LC, Tully I, Kiff S, Scheerer P, Reyes M, Paisdzior S, et al. A New Multisystem Disorder Caused by the Gαs Mutation p.F376V. Journal of Clinical Endocrinology & Metabolism. 2019;104 (4) :1079-1089. Publisher’s Version
2018
Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, et al. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. NPJ Genomic Medicine. 2018;3 (21) :eCollection. Publisher’s Version
Bove-Fenderson E, Mannstadt M. Hypocalcemic disorders. Best Practice & Research Clinical Endocrinology & Metabolism. 2018;32 (5) :639-656. Publisher’s Version
Biebermann H, Kleinau G, Schnabel D, Bockenhauer D, Wilson LC, Tully I, Kiff S, Scheerer P, Reyes M, Paisdzior S, et al. A new multi-system disorder caused by the Gαs mutation p.F376V. Journal of Clinical Endocrinology & Metabolism. 2018. Publisher’s Version
Fan Y, Liu W, Bi R, Densmore MJ, Sato T, Mannstadt M, Yaun Q, Zhou X, Olauson H, Larsson TE, et al. Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia. Proceedings of the National Academy of Sciences of the United States of America . 2018;115 (16) :E3749-E3758. Publisher’s Version
Goltzman D, Mannstadt M, Marcocci C. Physiology of the Calcium-Parathyroid Hormone-Vitamin D Axis. Frontiers of Hormone Research. 2018;50 :1-3. Publisher’s Version
Bove-Fenderson E, Duffy K, Mannstadt M. Sharing the Wealth: ASBMR Journals Update Policies on Data Sharing and Data Repositories. Journal of Bone and Mineral Research. 2018;33 (3) :369-370. Publisher’s Version
Bove-Fenderson E, Duffy K, Mannstadt M. Broadening Our Horizons: JBMR and JBMR Plus Embrace Preprints. Journal of Bone and Mineral Research. 2018;33 (2) :185-187. Publisher’s Version
Vokes TJ, Mannstadt M, Levine MA, Clarke BL, Lakatos P, Chen K, Piccolo R, Krasner A, Shoback DM, Bilezikian JP. Recombinant Human Parathyroid Hormone Effect on Health-Related Quality of Life in Adults With Chronic Hypoparathyroidism. Journal of Clinical Endocrinology & Metabolism. 2018;103 (2) :722-731. Publisher’s Version
2017
Vokes TJ, Mannstadt M, Levine MA, Clarke BL, Lakatos P, Chen K, Piccolo R, Krasner A, Shoback DM, Bilezikian JP. Recombinant Human Parathyroid Hormone Effect on Health-Related Quality of Life in Adults With Chronic Hypoparathyroidism. Journal of Clinical Endocrinology & Metabolism. 2017 :1-15. Publisher’s Version
Mannstadt M, Bilezikian JP, Thakker RV, Hannan FM, Clarke BL, Reijnmark L, Mitchell DM, Vokes TJ, Winer KK, Shoback DM. Hypoparathyroidism. Nature Reviews Disease Primers. 2017;3 :1-20. Publisher’s Version
Bi R, Fan Y, Yuan Q, Mannstadt M. Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation. Journal of Visualized Experiments. 2017;(121) :1-6
Stephen AE, Mannstadt M, Hodin RA. Indications for Surgical Management of Hyperparathyroidism: A Review. JAMA Surgery Review. 2017 :E1 – E5
Bi R, Yan Y, Luo E, Mannstadt M. Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glandsand Diphtheria-Toxin-Mediated Parathyroid Ablation. Journal of Visualized Experiments. 2017;(121) :1-6. Publisher’s Version
Roszko KL, Gorvin CM, Bräuner-Osborne H, Xiong XF, Inoue A, Thakker RV, Strømgaard K, Gardella T, Mannstadt M. Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. JCI Insight. 2017;2 (3) :1-15. Publisher’s Versio
Fan Y, Hanai J, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, et al. Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metabolism. 2017 :13.
2016
Xiong XF, Zhang H, Underwood CR, Harpsøe K, Gardella TJ, Wöldike MF, Mannstadt M, Gloriam DE, Bräuner-Osborne H, Strømgaard K. Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors. Nature Chemistry. 2016;8 :1035-1041.
Roszko KL, Bi DR, Mannstadt M. Autosomal Dominant Hypocalcemia (Hypoparathyroidism) Types 1 and 2. Frontiers in Physiology. 2016;7 (458).
Clarke BL, Vokes TJ, Bilezikian JP, Shoback DM, Lagast H, Mannstadt M. Effects of parathyroid hormone rhPTH (1-84) on phosphate homeostasis and vitamin D metabolism in hyporarathyroidism: REPLACE phase 3 study. Endocrine. 2016.
Pages
Clarke BL, Brown EM, Collins MT, Jüppner H, Lakatos P, Levine MA, Mannstadt M, Bilezikian JP, Romanischen AF, Thakker RV. Epidemiology and Diagnosis of Hypoparathyroidism. J Clin Endocrinol Metab. 2016;101 (6) :2284-2299.Abstract Epidemiology and Diagnosis of Hypoparathyroidism
Bilezikian JP, Brandi ML, Cusano NE, Mannstadt M, Rejnmark L, Rizzoli R, Rubin MR, Winer KK, Liberman UA, Potts JTJ. Management of Hypoparathyroidism: Present and Future. J Clin Endocrinol Metab. 2016;Epub ahead of print.Abstract Management_of_Hypoparathyroidism_JCEM_2016.pdf
R B, Y F, Lauter KB, Hu J, Watanabe T, Cradock J, Yuan Q, Gardella TJ, Mannstadt M. Diphtheria Toxin- and GFP-Based Mouse Models of Acquired Hypoparathyroidism and Treatment with a Long-Acting Parathyroid Hormone Analog. J Bone Miner Res. 2016;[Epub ahead of print].
2015
Lee SH, Mannstadt M, Guo J, Kim SM, Yi H-S, Khatri A, Dean T, Okazaki M, Gardella TJ, Jüppner H. A Homozygous [Cys25]PTH(1-84) Mutation that Impairs PTH/PTHrP Receptor Activation Defines a Novel form of Hypoparathyroidism. J Bone Miner Res. 2015
Monis EL, Mannstadt M. Hypoparathyroidism-disease update and emerging treatments. Ann Endocrinol (Paris). 2015;76 (2) :84-8.Abstract
2014
Dreijerink KMA, goudet P, burgess JR, Valk GD, International-Breast-Cancer-in-MEN1-Study-Group. Breast-cancer predisposition in multiple endocrine neoplasia type 1. N Engl J Med. 2014;371 (6) :583-4.
Mannstadt M, Lin AE, Le LP. Case records of the Massachusetts General Hospital. Case 24-2014. A 27-year-old man with severe osteoporosis and multiple bone fractures. N Engl J Med. 2014;371 (5) :465-72.
Eyal O, Oren A, Jüppner H, Somech R, De Bellis A, Mannstadt M, Szalat A, Bleiberg M, Weisman Y, Weintrob N. Hypoparathyroidism and central diabetes insipidus: in search of the link. Eur J Pediatr. 2014;173 (12) :1731-4
2013
Mannstadt M, Clarke BL, Vokes T, Brandi ML, Ranganath L, Fraser WD, Lakatos P, Bajnok L, Garceau R, Mosekilde L, et al. Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study. Lancet Diabetes Endocrinol. 2013;1 (4) :275-83
Mannstadt M, Harris M, Bravenboer B, Chitturi S, Dreijerink KMA, Lambright DG, Lim ET, Daly MJ, Gabriel S, Jüppner H. Germline mutations affecting Gα11 in hypoparathyroidism. N Engl J Med. 2013;368 (26) :2532-4.
Zhao W, Petit E, Gafni RI, Collins MT, Robey PG, Seton M, Miller KK, Mannstadt M. Mutations in NOTCH2 in patients with Hajdu-Cheney syndrome. Osteoporos Int. 2013;24 (8) :2275-81
2012
Yi H-S, Eom YS, Park IB, Lee S, Hong S, Jüppner H, Mannstadt M, Lee SH. Identification and characterization of C106R, a novel mutation in the DNA-binding domain of GCMB, in a family with autosomal-dominant hypoparathyroidism. Clin Endocrinol (Oxf). 2012;76 (5) :625-33.
Block GA, Wheeler DC, Persky MS, Kestenbaum B, Ketteler M, Spiegel DM, Allison MA, Asplin J, Smits G, Hoofnagle AN, et al. Effects of phosphate binders in moderate CKD. J Am Soc Nephrol. 2012;23 (8) :1407-15
Mannstadt M, Magen D, Segawa H, Stanley T, Sharma A, Sasaki S, Bergwitz C, Mounien L, Boepple P, Thorens B, et al. Fanconi-Bickel syndrome and autosomal recessive proximal tubulopathy with hypercalciuria (ARPTH) are allelic variants caused by GLUT2 mutations. J Clin Endocrinol Metab. 2012;97 (10) :E1978-86.
Mitchell DM, Regan S, Cooley MR, Lauter KB, Vrla MC, Becker CB, Burnett-Bowie S-AM, Mannstadt M. Long-term follow-up of patients with hypoparathyroidism. J Clin Endocrinol Metab. 2012;97 (12) :4507-14
2011
Mannstadt M, Holick E, Zhao W, Jüppner H. Mutational analysis of GCMB, a parathyroid-specific transcription factor, in parathyroid adenoma of primary hyperparathyroidism. J Endocrinol. 2011;210 (2) :165-71.
2008
Mannstadt M, Bertrand G, Muresan M, Weryha G, Leheup B, Pulusani SR, Grandchamp B, Jüppner H, Silve C. Dominant-negative GCMB mutations cause an autosomal dominant form of hypoparathyroidism. J Clin Endocrinol Metab. 2008;93 (9) :3568-76.
Gutiérrez OM, Mannstadt M, Isakova T, Rauh-Hain JA, Tamez H, Shah A, Smith K, Lee H, Thadhani R, Jüppner H, et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med. 2008;359 (6) :584-92.
Mannstadt M, Lorente C, Jüppner H. Rapid detection of intact FGF-23 in tumor tissue from patients with oncogenic osteomalacia. Clin Chem. 2008;54 (7) :1252-4. rapid_fgf_clin_chem.pdf
2007
Bazari H, Jaff MR, Mannstadt M, Yan S. Case records of the Massachusetts General Hospital. Case 7-2007. A 59-year-old woman with diabetic renal disease and nonhealing skin ulcers. N Engl J Med. 2007;356 (10) :1049-57. cpc_calciphylaxis_nejmcpc069038.pdf
Pages
2004
Schindler S, Mannstadt M, Urena P, Segre GV, Stein G. PTH secretion in patients with chronic renal failure assessed by a modified CiCa clamp method: effects of 1-year calcitriol therapy. Clin Nephrol. 2004;61 (4) :253-60
2001
White KE, Jonsson KB, Carn G, Hampson G, Spector TD, Mannstadt M, Lorenz-Depiereux B, Miyauchi A, Yang IM, Ljunggren O, et al. The autosomal dominant hypophosphatemic rickets (ADHR) gene is a secreted polypeptide overexpressed by tumors that cause phosphate wasting. J Clin Endocrinol Metab. 2001;86 (2) :497-500
Jonsson KB, Mannstadt M, Miyauchi A, Yang IM, Stein G, Stein G, Jüppner H. Extracts from tumors causing oncogenic osteomalacia inhibit phosphate uptake in opossum kidney cells. J Endocrinol. 2001;169 (3) :613-20.
2000
Brenner-Maucher K, Szeimies U, Mannstadt M, Gross M. [Fasciola hepatica: the sonographic and computed tomographic changes in a case with a liver fluke]. Rofo. 2000;172 (6) :562-3.
Mannstadt M, Sing A, Leitritz L, Brenner-Maucher K, Bogner J. Conservative management of biliary obstruction due to Fasciola hepatica. Clin Infect Dis. 2000;31 (5) :1301-3.
1999
Mannstadt M, Jüppner H, Gardella TJ. Receptors for PTH and PTHrP: their biological importance and functional properties. Am J Physiol. 1999;277 (5 Pt 2) :F665-75.
1998
Mannstadt M, Luck MD, Gardella TJ, Jüppner H. Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies. J Biol Chem. 1998;273 (27) :16890-6
Jüppner H, Schipani E, Bastepe M, Cole DE, Lawson ML, Mannstadt M, Hendy GN, Plotkin H, Koshiyama H, Koh T, et al. The gene responsible for pseudohypoparathyroidism type Ib is paternally imprinted and maps in four unrelated kindreds to chromosome 20q13.3. Proc Natl Acad Sci U S A. 1998;95 (20) :11798-803.
1997
Mannstadt M. [The knockout mouse–a revolutionizing model in biomedical research]. Med Klin (Munich). 1997;92 (9) :558-60.
Mannstadt M, Drüeke TB. [Parathyroid hormone receptors: from cloning to physiological, physiopathological and clinical implications]. Nephrologie. 1997;18 (1) :5-10.
1996
Hruby M, Ureña P, Mannstadt M, Schmitt F, Lacour B, Drüeke TB. Effects of new vitamin D analogues on parathyroid function in chronically uraemic rats with secondary hyperparathyroidism. Nephrol Dial Transplant. 1996;11 (9) :1781-6.
1995
Mannstadt M, Touam M, Fink E, Ureña P, Hruby M, Zingraff J, Uhlenbusch-Körwer I, Grassmann A, Lemke HD, Drüeke TB. No generation of bradykinin with a new polyacrylonitrile membrane (SPAN) in haemodialysis patients treated with ACE inhibitors. Nephrol Dial Transplant. 1995;10 (9) :1696-700.
Ureña P, Mannstadt M, Hruby M, Ferreira A, Schmitt F, Silve C, Ardaillou R, Lacour B, Abou-Samra AB, Segre GV. Parathyroidectomy does not prevent the renal PTH/PTHrP receptor down-regulation in uremic rats. Kidney Int. 1995;47 (6) :1797-805.
1994
Ureña P, Kubrusly M, Mannstadt M, Hruby M, Trinh MM, Silve C, Lacour B, Abou-Samra AB, Segre GV, Drüeke T. The renal PTH/PTHrP receptor is down-regulated in rats with chronic renal failure. Kidney Int. 1994;45 (2) :605-11.
Ureña P, Kubrusly M, Mannstadt M, Sarfati E, Drüeke T. Total or subtotal parathyroidectomy in uremic patients?. Clin Nephrol. 1994;41 (1) :59-60.