Principal Investigator
Michael Mannstadt, MD
Associate Professor at Harvard Medical School
MGH Endocrine Unit Chief
Michael Mannstadt, MD, is an endocrinologist at Massachusetts General Hospital in Boston. He received his MD from Jena University, Germany. He completed his residency training in Internal Medicine and a clinical fellowship in Endocrinology, Diabetes and Metabolism, at Massachusetts General Hospital.
Dr. Mannstadt established his laboratory within the Endocrine Unit of Massachusetts General Hospital. His research focuses on parathyroid function and disease including (1) understanding the genetic basis of familial hypoparathyroidism; (2) defining the mechanisms by which the newly identified genes and pathways impact parathyroid function; (3) using these insights to improve treatment for parathyroid disorders. His basic research also investigates the transcriptional network of parathyroid cells. His clinical research focuses in particular on hypoparathyroidism and his research group analyzed one of the largest patient series in hypoparathyroidism. This study reveals significant shortcomings of our current therapy. Recognizing the limitations of current therapies, he became the Principal Investigator of an NIH grant for the development of a long-acting PTH, and is the lead author of the phase 3 clinical trial of PTH(1-84) in hypoparathyroidism. He is a Medical Advisor for the Hypoparathyroid Association and a frequent faculty participant at their annual patient meetings. He has participated in the development of guidelines for the management of hypoparathyroidism.
Lab Members
Nipith Charoenngam
Researcher
nipith.charoenngam@mah.harvard.edu
Nipith Charoenngam, MD, is a resident in internal medicine at Mt. Auburn Hospital and is working with Dr. Mannstadt on several research projects.
Andria Fremaint
Clinical Research Coordinator
afremaint@mgh.harvard.edu
Andria Fremaint is a Clinical Research Coordinator working with Dr. Mannstadt as the MGH site study coordinator for the international Hypoparathyroidism Registry PARADIGHM. She earned a BA degree from the College of Holy Cross in Psychology with a Latin American Studies Concentration.
Olga Katsovskiy
Program Manager
okatsovskiy@mgh.harvard.edu
Olga Katsovskiy, MHA, is a Program Manager in the Endocrine Unit. She has a Bachelor’s of Science and holds a Master of Health Administration from Ohio University.
Sung-Hee (Seanna) Yoon
Research Fellow
syoon9@mgh.harvard.edu
Sung-Hee (Seanna) Yoon, PhD, is a Research Fellow working with Drs. Michael Mannstadt and Marc Wein. Dr. Yoon earned her MS from the University of Toronto, along with a PhD from the Graduate Department of Pharmacology and Toxicology, Canada.
Cameron J. Young
Research Technician
cyoung17@mgh.harvard.edu
Cameron J. Young is a Research Technician in Dr. Mannstadt’s laboratory in the Endocrine Unit. He completed his Bachelor’s in Biology at Assumption College and has a passion for research and experiences in biology, including cellular and molecular biology, biochemistry, genetics, and immunology.
Anne-Laure Bonnet
Research Fellow
abonnet@mgh.harvard.edu
Anne-Laure Bonnet, PhD, DDS, MS, is a Research Fellow. She is an Assistant Professor in Pediatric Dentistry at Paris Cité University, where she earned her PhD in Development, Genetics, and Neurobiology. She is working on projects related to the parathyroid glands’ biology, and the learning of i-GONAD and the generation and characterization of mouse models in Dr. Mannstadt’s laboratory.
Former Group Members
2021 – 2022
Laura Cooke – Clinical Research Coordinator
Laura earned her Bachelor of Music in Cello Performance with a Minor in Anthropology at Vanderbilt University in 2016. She was the MGH site study coordinator for the international Hypoparathyroidism Registry PARADIGHM. She is now attending Tufts Medical School.
2016 – 2022
Han Xie – Research Technician
Han is an experienced Research Technician who gained work experience at Indiana University, Dean Foods Company, and Beth Israel Deaconess Medical Center in Boston before joining my lab.
2017 – 2021
Lauren Surface – Instructor in Medicine
Lauren Surface, PhD, earned her degree in 2014 from the Massachusetts Institute of Technology. Her experience spans genetic screens and molecular biology to organismal signaling and bone physiology with ongoing immersion and exposure to experimental and clinical approaches.
2017 – 2021
Ian Li – Research Fellow
Ian Li, PhD, joined the unit in 2017 after earning his PhD in Musculoskeletal Biology at the University of Liverpool, UK, where he received 1st class hours.
2019 – 2020
Chang Liu – Research Fellow
Chang Liu, MD, is a PhD candidate in Internal Medicine at Peking Union Medical Collage in Beijing, China. She worked on the directed differentiation of human iPS cells towards parathyroid cells.
2017 – 2020
Erin Bove-Fenderson – Science Writer
Erin Bove-Fenderson, PhD, worked in the Mannstadt lab as a medical/science writer. She holds a PhD from the Biochemistry Department at Boston University School of Medicine, where she studied the molecular mechanisms of Alzheimer’s Disease.
2017 – 2019
Feng Lou – Research Fellow
Feng Lou, DMD, PhD, completed his education at the West China School of Stomatology, Sichuan Univerisity. He worked on the transcriptional regulation of the parathyroids.
2019
Bernstein – Summer Student
As a high school student at Buckingham Browne & Nichols School, Samantha participated in lab work with Dr. Lauren Surface to get first impressions on how a research laboratory works.
2018
Guido van Leeuwen – Graduate Student
Guido has a Bachelor’s in Medicine from VU University in Amsterdam and worked on mouse parathyroid cells with Dr. Li as part of his MD program internship at the VUmc school of Medical Sciences.
2016 – 2018
Emily Gentile – Clinical Research Assistant
Emily graduated from the George Washington University in May 2016 with a degree in public health, after which she joined the Endocrine Unit at Massachusetts General Hospital as a Clinical Research Assistant. Emily worked on both on an extension study of a long-term open label clinical trial investigating full-length recombinant human PTH(1-84) as a replacement therapy in patients with hypoparathyroidism, and a registry study examining the natural history of chronic hypoparathyroidism.
2014 – 2017
Kelly Lauter Roszko – Research Fellow
Dr. Lauter’s interest in Endocrinology began during her M.D., Ph.D. training at the University of Connecticut (supervisor Dr. Andrew Arnold). After completing residency and Endocrine fellowship at The Massachusetts General Hospital, Kelly worked in Dr. Mannstadt’s laboratory where she created and studied a mouse model for Autosomal-dominant hypocalcemia 2.
2013 – 2016
Bi “David” Ruiye – Research Fellow
Bi “David” Ruiye, DMD, received his dental degree at Sichuan University in Chengdu, China, the oldest and most prestigious dental school in China. He entered a PhD program and joined the Endocrine Unit in March 2013. David developed animal models of hypoparathyroidism and showed the ability of long-acting PTH to correct the mineral abnormalities, a promising approach for the treatment of this disease.
2015
Felicitas Huber – Medical Student
Felicitas came from the LMU University in Munich, Germany and worked as a summer intern to gain research experience.
2014
Jamasb Sayadi – Intern
Jamasb worked under my supervision as a student of the Harvard Stem Cell Institute (HSCI) Summer Internship Program (HIP) to gain exposure to a research laboratory. He was accepted at Stanford’s MD/PhD program.
2013 – 2016
Elizabeth Monis – Clinical Coordinato
Elizabeth served as a study coordinator for clinical trials investigating rhPTH(1-84) in hypoparathyroidism. Elizabeth went to Medical School.
2012 – 2013
Adam Roy – Clinical Coordinator
Adam served as a study coordinator for clinical trials investigating rhPTH(1-84) in hypoparathyroidism, went to Medical School.
2010 – 2011
Michael Vrla – Clinical Coordinator
Michael served as study coordinator for clinical trials investigating rhPTH(1-84) in hypoparathyroidism. He was accepted at Medical School.
2009 – 2016
Wenping Zhao – Research Fellow
Dr. Zhao worked as a Research Fellow on characterization of the function of a parathyroid-specific transcription factor using knock-in mice and ChIP-seq, allowing him to develop and enhance his research skills and earning promotion to Instructor at HMS. Dr. Zhao started a research position in industry.
2009 – 2011
Elizabeth Petit – Research Assistant
Elizabeth served as a Research Assistant in the wet lab, mastering ELISA assays.
2009 – 2010
Emily Holick – Research Technician
Emily worked as a lab technician in molecular biology and joined the MD/PhD program at Boston University.
2008 – 2009
Elizabeth McKay – Clinical Coordinator
Emily served as a study coordinator for the pivotal phase 3 trial investigating human recombinant PTH(1-84) for hypoparathyroidism. She was accepted at Medical School.